IBS and the Stress Connection, Part 1

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If you or someone you know has been diagnosed with Irritable Bowel Syndrome (IBS), you may already know it is a diagnosis of exclusion. You have been tested for everything under the sun and still no definitive answers. This is part of the reason why frustration and prolonged or severe digestive complaints becomes a common scenario for many IBS sufferers. But there is hope!

Follow me on a path of discovery in my three-part article series with ELM Magazine to help answer some of your questions, create better understanding of a complicated disorder, and provide tools to help you get your health back on track. Click the link below to learn more.

The Link Between Stress and IBS, Part 1


RESOURCES FOR PART 1:

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[11] Lackner JM, Ma CX, Keefer L, et al. Type, rather than number, of mental and physical comorbidities increases the severity of symptoms in patients with irritable bowel syndrome. Clin Gastroenterol Hepatol 2013; 11: 1147-1157.

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[13] Longstreth GF. Definition and classification of irritable bowel syndrome: current consensus and controversies. Gastroenterol Clin North Am 2005; 34: 173-187.

[14] Selye, H. The physiology and pathology of exposure to stress, a treatise based on the concepts of the general-adaptation-syndrome and the diseases of adaptation. Montreal: ACTA, In., Medical Publishers; 1950.

[15] Choung RS, Lock GR 3rd, Zinsmeister AR, Schleck CD, Talley NJ. Psychosocial distress and somatic symptoms in community subjects with irritable bowel syndrome: a psychological component is the rule. Am J Gastroenterol. 2009; 104: 1772-1779.

[16] Guilliams, TG. The role of stress and the HPA axis in chronic disease management. Stevens Point, WI: Point Institute; 2015.

[17] Rea K, Dinan TG, Cryan JF. The microbiome, a key regulator of stress and neuroinflammation. Neurobiol Stress. 2016 Oct; 4: 23-33.

[18] Heisler LK, Pronchuk N, Nonogaki K, et al. Serotonin activates the hypothalamic-pituitary-adrenal axis via serotonin 2C receptor stimulation. The Journal of Neuroscience. 2007 Jun; 27(26): 6956-6964.

[19] Barreau F, Cartier C, Leveque M, et al. Pathways involved in gut mucosal barrier dysfunction induced in adult rats by maternal deprivation: corticotrophin-releasing factor and nerve growth factor interplay. J Physiol 2007; 580: 347-356.

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[21] Remes-Troche JM, Torres-Aguilera M, Motes-Martinez V, Jimenez-Garcia VA, Roesch-Dietlen F. Prevalence of irritable bowel syndrome in caregivers of patients with chronic diseases. Neurogastroenterology & Motility. 2015; 27(6); 824-831.

[22] Koloski NA, Jones M, Talley NJ. Evidence that independent gut-to-brain and brain-to-gut pathways operate in the irritable bowel syndrome and functional dyspepsia: a 1-year population-based prospective study. Alimentary Pharmacology & Therapeutics. 2016; 44(6): 592-600.

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[25] Spiller RC, Jenkins D, Thornley JP, Hebden JM, Wright T, Skinner M, Neal KR. Increased rectal mucosal Enteroendocrine cells, T lymphocytes, and increasec gut permeability following acute Campylobacter enteritis and in post-dysenteric irritable bowel syndrome. Gut. 2000; 47: 804-811.

[26] Zhou Q, Zhang B, Verne GN. Intestinal membrane permeability and hypersensitivity in the irritable bowel syndrome. Pain. 2009; 146: 41-46.

[27] Piche T, Saint-Paul MC, Dainese R, et al. Mast cells and cellularity of the colonic mucosa correlated with fatigue and depression in irritable bowel syndrome. Gut. 2008; 57: 468-473.

[28] Vivinus-Nebot M, Dainese R, Galliani EA, et al. Combination of allergic factors can worsen diarrheic irritable bowel syndrome: role of barrier defects and mast cells. Am J Gastroenterol. 2012; 107: 75-81.

[29] Alt-Belgnaoui A, et al. Prevention of gut leakiness by a probiotic treatment leads to attenuated HPA response to an acute psychological stress in rats. Psychoneuroendocrinology. 2012; 37: 1885-1895.

[30] Cremon C, Carini G, Wang B, et al. Intestinal serotonin release, sensory neuron activation, and abdominal pain in irritable bowel syndrome. Am J Gastroenterol. 2011; 106: 1290-1298.

[31] Collins SM, Piche T, Rampal P. The putative role of inflammation in the irritable bowel syndrome. Gut. 2001; 49: 743-745.

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